The first consideration for any vaccine development program should be the generation of a target product profile or TPP. This will outline the desired characteristics of the vaccine product that is under development. It generally identifies the “optimal target” and a “minimal target” and should include status updates of completed or planned studies that support …
mRNA vaccines for Veterinary use – Practical review Read More »
In order for any vaccine to be manufactured in GMP conditions it is necessary to first produce a ‘Master Seed Bank’ which is basically a bank of cells, bacteria, virus and or yeast with enough the vaccine manufacture for the product life cycle. The cell bank is the progenitor of all batches of the vaccine …
While AI has been a popular topic, its practical application in veterinary vaccine production is still in its early stages. The potential of AI for data analysis, predictions, and epitope predictions is vast, and we are just beginning to explore how these approaches can be applied to the production of current vaccines, particularly in a …
Practical Approach to the Use of AI for Veterinary Vaccine Production Read More »
This article is to shade light on CMO/CRA/CMO or partnership selections and management, an extremely challenge aspect of the business. Based on my experience, the approach should be the same for development, research, or manufacturing. Of course, specific deliverables may vary, but the overall process remains consistent. For semantic purposes we will use CMO in …
How to handle Contract manufacture partners (CDMO, CRO, CMO)?! Read More »
The objective of this study is to ascertain the potential size of the animal health market. While it is challenging to determine the exact size of this market, we can make an estimate by identifying the major players and the target animal populations. Our analysis will primarily focus on vaccines for cattle, poultry, and swine. …
What is the veterinary market now and in the future …. Read More »
For any oil-water/water in our or Water–oil–water emulsion measurement employing liquid-liquid extraction, the laboratory must use emulsion-breaking techniques to complete the phase separation if the emulsion exceeds one-third of the solvent layer’s volume. It is essential to remember that if the emulsion cannot be broken, the test method may not provide accurate results for the …
BREAKING EMULSIONS OF VACCINES – EASY AND UNCOMPLICATED PROTOCOLS Read More »
A client reached out to me a few months ago in extreme worry. He had been facing a serious issue with his emulsion, with not one but 11 batches being contaminated. The total loss due to this contamination was estimated to be around 200 million euros. The client was perplexed about how this could have …
How to investigate a contaminated emulsion: From raw material to the final Emulsion. Read More »
This work was presented as the most challenging work performed so far and the most fantastic opportunity. We removed the saponin and increased the production for this client by more than 40% – a genuine crisis that became an opportunity. During a recent client engagement, the client and I were taken aback by the new …
Removing the Saponin and increasing the production capacity by 40%. Read More »
I initially hesitated before writing this article since media fill is not directly related to emulsions, and I am not an expert in the aseptic process. However, during my production journey, I encountered one of the most challenging times while conducting media fill simulations. When I joined this particular company, it was a large organization …
Squalene, a hydrocarbon that acts as a boosting agent, is an essential ingredient in the production of vaccines and is primarily obtained from shark liver oil for commercial purposes. The primary benefit of squalene is that it improves the immune system and makes vaccines more effective. Although all sharks have squalene, the deep-sea species have …